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A Markdown file or a notebook output can carry a button that runs a JupyterLab command. Since 4.5.7 the first click on such a button opens a prompt naming the command, with Cancel, Run Once and Trust. Choosing Trust runs the command and marks the document trusted, so its later buttons run without a prompt.

JupyterLab 4.5.0 enabled copying and pasing cells through the system clipboard. The paste path parses clipboard text as cell JSON and inserts the cells without clearing metadata.trusted, so a payload can declare its own output as trusted. JupyterLab does not sanitize a trusted output and evaluates the <script> elements it contains, so pasting the cell runs attacker's JavaScript in the JupyterLab origin. The same payload with "trusted": false is sanitized.